Study of Various Morphological Types of Anaemia in Patients with Rheumatoid Arthritis and Comparison of Serum Ferritin with Bone Marrow Iron Stores in These Patients
نویسنده
چکیده
This was a prospective study conducted in the Postgraduate Department of Pathology, ASCOMS Sidhra, Jammu over a period of one year. The aims of this study were to study the various morphological types of anaemia in patients of rheumatoid arthritis and also to study the correlation between serum ferritin and bone marrow iron stores in these patients. It was inferred from the study that the normocytic normochromic anaemia (76.5%) was the most common morphological type of anaemia in the study group and that there existed a positive correlation (point biserial correlation coefcient = 0.539, p=0.001) between serum ferritin and bone marrow iron stores in the study subjects.
منابع مشابه
Anaemia of rheumatoid arthritis: serum erythropoietin concentrations and red cell distribution width in relation to iron status.
Immunoreactive serum erythropoietin concentrations were measured in 35 patients with anaemia associated with active rheumatoid arthritis. Based on an evaluation of stainable iron in the bone marrow (marrow iron grade 0-4) and serum ferritin concentrations (concentrations less than or equal to 60 micrograms/l compatible with iron deficiency) the anaemia was found to be complicated by iron defici...
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Serum ferritin concentration has been compared with semi-quantitative histochemical estimates of bone marrow iron deposits in 60 anaemic patients with rheumatoid arthritis. There was considerable variation in the visual assessment of iron stores made by different observers. Serum ferritin appears to be a particularly sensitive index of iron status when stores are low. The best means of detectin...
متن کاملIron in rheumatoid arthritis.
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Background and Objectives: Rheumatoid arthritis (RA) disease is a common inflammatory arthritis associated with joint destruction, motor disorder, and decreased life span. Hepcidin is an acute phase reactant protein which increases in inflammatory conditions mediated by IL-6 and its concentration elevates within the cell through regulating iron metabolism. The aim of this study was to evaluate ...
متن کاملSerum transferrin receptor, serum ferritin and serum transferrin receptor-ferritin index in adults with iron deficiency anaemia.
BACKGROUND Serum Ferritin (SF) and iron both show acute phase responses to inflammation, so iron may fall and ferritin rise independent of the marrow iron store. Bone marrow iron store has been considered the gold standard, but is invasive, painful and expensive and not suitable for everyone. Serum transferrin receptor (sTfR) which is the concentration of the soluble fragment of transferrin rec...
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